Drug interactions
Daridorexant + Enzalutamide
Severity: Major
Daridorexant and Enzalutamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide strongly lowers daridorexant exposure, likely rendering it ineffective for insomnia.
What this interaction means in plain words
Daridorexant and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daridorexant belongs to Central Nervous System; Enzalutamide belongs to Endocrine.
Why it happens
CYP3A4 induction by enzalutamide increases the metabolism of daridorexant.
What to do
Avoid use with strong CYP3A inducers per labeling. Choose an alternative hypnotic not dependent on CYP3A4.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Enzalutamide?
MediHelp rates the interaction as major. Daridorexant and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide strongly lowers daridorexant exposure, likely rendering it ineffective for insomnia.
How serious is the interaction between Daridorexant and Enzalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use with strong CYP3A inducers per labeling. Choose an alternative hypnotic not dependent on CYP3A4.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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