Drug interactions
Daridorexant + Itraconazole
Severity: Major
Daridorexant and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole substantially increases daridorexant exposure, which can cause excessive sedation, next-day somnolence and impaired psychomotor performance. Labeling advises against use with strong CYP3A4 inhibitors.
What this interaction means in plain words
Daridorexant and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daridorexant belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces daridorexant metabolism.
What to do
Avoid the combination and use an alternative antifungal or hypnotic. If an interacting course is unavoidable, do not drive and monitor for excessive sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Itraconazole?
MediHelp rates the interaction as major. Daridorexant and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole substantially increases daridorexant exposure, which can cause excessive sedation, next-day somnolence and impaired psychomotor performance. Labeling advises against use with strong CYP3A4 inhibitors.
How serious is the interaction between Daridorexant and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antifungal or hypnotic. If an interacting course is unavoidable, do not drive and monitor for excessive sedation.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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