Drug interactions
Daridorexant + Fluvoxamine
Severity: Major
Daridorexant and Fluvoxamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine moderately inhibits CYP3A4, increasing daridorexant exposure and the risk of next-day somnolence and psychomotor impairment. Additive CNS depression may occur.
What this interaction means in plain words
Daridorexant and Fluvoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daridorexant belongs to Central Nervous System; Fluvoxamine belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition reducing daridorexant clearance, plus additive CNS depressant effects.
What to do
Limit daridorexant to a maximum of 25 mg nightly. Counsel patients about daytime drowsiness and driving impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Fluvoxamine?
MediHelp rates the interaction as major. Daridorexant and Fluvoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluvoxamine moderately inhibits CYP3A4, increasing daridorexant exposure and the risk of next-day somnolence and psychomotor impairment. Additive CNS depression may occur.
How serious is the interaction between Daridorexant and Fluvoxamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit daridorexant to a maximum of 25 mg nightly. Counsel patients about daytime drowsiness and driving impairment.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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