Drug interactions
Carbidopa-entacapone-levodopa + Dicyclomine
Severity: Moderate
Carbidopa-entacapone-levodopa and Dicyclomine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dicyclomine is an anticholinergic that can add to confusion, hallucinations and dyskinesia in patients taking levodopa. It slows gastric emptying and may delay levodopa absorption, reducing its effect.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Dicyclomine belongs to Respiratory.
Why it happens
Additive anticholinergic effects with delayed gastric emptying reducing levodopa absorption.
What to do
Monitor for cognitive effects and changes in motor response, especially in older adults. Use the lowest effective dicyclomine dose or choose a non-anticholinergic option.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Dicyclomine?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dicyclomine is an anticholinergic that can add to confusion, hallucinations and dyskinesia in patients taking levodopa. It slows gastric emptying and may delay levodopa absorption, reducing its effect.
How serious is the interaction between Carbidopa-entacapone-levodopa and Dicyclomine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cognitive effects and changes in motor response, especially in older adults. Use the lowest effective dicyclomine dose or choose a non-anticholinergic option.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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