Drug interactions
Carbidopa-entacapone-levodopa + Eplerenone
Severity: Minor
Carbidopa-entacapone-levodopa and Eplerenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause hypotension and orthostatic intolerance, which may add to the blood pressure lowering effect of eplerenone. The effect is usually modest but can cause dizziness or falls.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Eplerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Eplerenone belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects of levodopa and an aldosterone antagonist.
What to do
Check blood pressure including orthostatic readings when starting or changing either drug. Reduce the antihypertensive dose if symptomatic hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Eplerenone?
MediHelp rates the interaction as minor. Carbidopa-entacapone-levodopa and Eplerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levodopa can cause hypotension and orthostatic intolerance, which may add to the blood pressure lowering effect of eplerenone. The effect is usually modest but can cause dizziness or falls.
How serious is the interaction between Carbidopa-entacapone-levodopa and Eplerenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure including orthostatic readings when starting or changing either drug. Reduce the antihypertensive dose if symptomatic hypotension develops.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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