Drug interactions
Carbidopa-entacapone-levodopa + Esmolol
Severity: Moderate
Carbidopa-entacapone-levodopa and Esmolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause hypotension, and esmolol reduces heart rate and blood pressure, so the effects may add together. This matters mostly in patients who are volume depleted or already prone to orthostatic hypotension.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Esmolol belongs to Cardiovascular.
Why it happens
Additive hypotensive pharmacodynamic effects of levodopa and beta-blockade.
What to do
Monitor blood pressure and heart rate during esmolol infusion. Titrate esmolol to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Esmolol?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause hypotension, and esmolol reduces heart rate and blood pressure, so the effects may add together. This matters mostly in patients who are volume depleted or already prone to orthostatic hypotension.
How serious is the interaction between Carbidopa-entacapone-levodopa and Esmolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during esmolol infusion. Titrate esmolol to response.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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