Drug interactions
Carbidopa-entacapone-levodopa + Ethacrynic acid
Severity: Moderate
Carbidopa-entacapone-levodopa and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a loop diuretic that lowers blood pressure and causes volume depletion, while levodopa can cause orthostatic hypotension. Together they may increase dizziness and fall risk.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from diuretic-induced volume depletion and levodopa-related autonomic and vasodilatory actions.
What to do
Monitor blood pressure including standing measurements and review diuretic dosing if orthostatic symptoms appear. Ensure adequate hydration and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Ethacrynic acid?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a loop diuretic that lowers blood pressure and causes volume depletion, while levodopa can cause orthostatic hypotension. Together they may increase dizziness and fall risk.
How serious is the interaction between Carbidopa-entacapone-levodopa and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including standing measurements and review diuretic dosing if orthostatic symptoms appear. Ensure adequate hydration and electrolytes.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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