Drug interactions
Carbidopa-entacapone-levodopa + Ferric maltol
Severity: Moderate
Carbidopa-entacapone-levodopa and Ferric maltol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron binds levodopa and entacapone in the gut, forming chelates that reduce absorption. This can lessen levodopa effect and lead to worsening of Parkinson symptoms. Entacapone also chelates iron, which may reduce iron uptake.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Ferric maltol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Ferric maltol belongs to Miscellaneous.
Why it happens
Chelation of levodopa and entacapone by ferric iron in the gastrointestinal tract reduces absorption.
What to do
Separate oral ferric maltol from the levodopa combination by at least 2 hours. Monitor motor symptoms and iron indices.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Ferric maltol
- Aluminum hydroxide + Ferric maltol Moderate
- Calcium carbonate + Ferric maltol Moderate
- Calcium + Ferric maltol Moderate
- Carbidopa-levodopa + Ferric maltol Moderate
- Cimetidine + Ferric maltol Moderate
- Ciprofloxacin + Ferric maltol Moderate
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Ferric maltol?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Ferric maltol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron binds levodopa and entacapone in the gut, forming chelates that reduce absorption. This can lessen levodopa effect and lead to worsening of Parkinson symptoms. Entacapone also chelates iron, which may reduce iron uptake.
How serious is the interaction between Carbidopa-entacapone-levodopa and Ferric maltol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral ferric maltol from the levodopa combination by at least 2 hours. Monitor motor symptoms and iron indices.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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