Drug interactions
Carbidopa-entacapone-levodopa + Iloperidone
Severity: Moderate
Carbidopa-entacapone-levodopa and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone blocks dopamine D2 receptors and can counteract levodopa benefit. This may worsen motor symptoms in Parkinson disease.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism via dopamine D2 receptor blockade.
What to do
Avoid if possible; if an antipsychotic is required in Parkinson disease, use quetiapine or clozapine. Monitor motor function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Iloperidone?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone blocks dopamine D2 receptors and can counteract levodopa benefit. This may worsen motor symptoms in Parkinson disease.
How serious is the interaction between Carbidopa-entacapone-levodopa and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if an antipsychotic is required in Parkinson disease, use quetiapine or clozapine. Monitor motor function.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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