Drug interactions
Carbidopa-entacapone-levodopa + Lurasidone
Severity: Moderate
Carbidopa-entacapone-levodopa and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone blocks dopamine D2 receptors and can oppose the benefit of levodopa, worsening parkinsonian motor symptoms. Both agents can also cause orthostatic hypotension. Lurasidone is less likely than older antipsychotics to cause this, but the risk remains.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors, with additive orthostatic hypotension.
What to do
Monitor motor function and orthostatic blood pressure. For psychosis in Parkinson's disease, prefer quetiapine or clozapine over lurasidone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Lurasidone?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone blocks dopamine D2 receptors and can oppose the benefit of levodopa, worsening parkinsonian motor symptoms. Both agents can also cause orthostatic hypotension. Lurasidone is less likely than older antipsychotics to cause this, but the risk remains.
How serious is the interaction between Carbidopa-entacapone-levodopa and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor function and orthostatic blood pressure. For psychosis in Parkinson's disease, prefer quetiapine or clozapine over lurasidone.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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