Drug interactions
Carbidopa-entacapone-levodopa + Macimorelin
Severity: Moderate
Carbidopa-entacapone-levodopa and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can stimulate growth hormone release, which may confound the macimorelin growth hormone stimulation test. This could cause a false-negative result and lead to missed diagnosis of growth hormone deficiency.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Macimorelin belongs to Endocrine.
Why it happens
Levodopa transiently increases growth hormone secretion, interfering with test interpretation.
What to do
Where clinically possible, withhold levodopa for an adequate washout period before macimorelin testing, or interpret results cautiously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Macimorelin?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can stimulate growth hormone release, which may confound the macimorelin growth hormone stimulation test. This could cause a false-negative result and lead to missed diagnosis of growth hormone deficiency.
How serious is the interaction between Carbidopa-entacapone-levodopa and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where clinically possible, withhold levodopa for an adequate washout period before macimorelin testing, or interpret results cautiously.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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