Drug interactions
Carbidopa-entacapone-levodopa + Metoprolol
Severity: Moderate
Carbidopa-entacapone-levodopa and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can lower blood pressure and cause orthostatic hypotension, and a beta-blocker such as metoprolol adds to the blood pressure reduction. The effect is usually manageable but may cause dizziness or falls.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Metoprolol belongs to Cardiovascular.
Why it happens
Additive hypotensive effect, as levodopa-derived dopamine reduces sympathetic tone and vascular resistance.
What to do
Monitor blood pressure and orthostatic symptoms when levodopa is started or increased. Reduce the beta-blocker dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Metoprolol?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can lower blood pressure and cause orthostatic hypotension, and a beta-blocker such as metoprolol adds to the blood pressure reduction. The effect is usually manageable but may cause dizziness or falls.
How serious is the interaction between Carbidopa-entacapone-levodopa and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when levodopa is started or increased. Reduce the beta-blocker dose if hypotension occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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