Drug interactions
Carbidopa-levodopa + Cyclizine
Severity: Minor
Carbidopa-levodopa and Cyclizine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine has anticholinergic properties that may modestly help parkinsonian symptoms but can worsen dyskinesias, confusion and constipation. At higher doses, delayed gastric emptying may reduce levodopa absorption.
What this interaction means in plain words
Carbidopa-levodopa and Cyclizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbidopa-levodopa belongs to Central Nervous System; Cyclizine belongs to Respiratory.
Why it happens
Anticholinergic effects slow gastric emptying and may delay levodopa absorption, with additive central anticholinergic effects.
What to do
Monitor motor response, cognition and bowel function. Prefer a non-dopamine-blocking antiemetic with less anticholinergic activity, such as domperidone, where nausea treatment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Contraindicated
- Carbidopa-levodopa + Phenelzine Contraindicated
- Carbidopa-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-levodopa Major
- Asenapine + Carbidopa-levodopa Major
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Carbidopa-levodopa with Cyclizine?
MediHelp rates the interaction as minor. Carbidopa-levodopa and Cyclizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclizine has anticholinergic properties that may modestly help parkinsonian symptoms but can worsen dyskinesias, confusion and constipation. At higher doses, delayed gastric emptying may reduce levodopa absorption.
How serious is the interaction between Carbidopa-levodopa and Cyclizine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor response, cognition and bowel function. Prefer a non-dopamine-blocking antiemetic with less anticholinergic activity, such as domperidone, where nausea treatment is needed.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
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