Drug interactions
Carbidopa-levodopa + Quetiapine
Severity: Moderate
Carbidopa-levodopa and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine has weak D2 blockade and is commonly used in Parkinson's psychosis, but it can occasionally worsen motor symptoms. Additive orthostatic hypotension and sedation may occur.
What this interaction means in plain words
Carbidopa-levodopa and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-levodopa belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Weak, transient D2 antagonism by quetiapine may oppose levodopa, with additive hypotensive and sedative effects.
What to do
Use the lowest effective quetiapine dose and monitor motor function and orthostatic blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Contraindicated
- Carbidopa-levodopa + Phenelzine Contraindicated
- Carbidopa-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-levodopa Major
- Asenapine + Carbidopa-levodopa Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Carbidopa-levodopa with Quetiapine?
MediHelp rates the interaction as moderate. Carbidopa-levodopa and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine has weak D2 blockade and is commonly used in Parkinson's psychosis, but it can occasionally worsen motor symptoms. Additive orthostatic hypotension and sedation may occur.
How serious is the interaction between Carbidopa-levodopa and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective quetiapine dose and monitor motor function and orthostatic blood pressure.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
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