Drug interactions
Carbinoxamine + Clonazepam
Severity: Moderate
Carbinoxamine and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine and adds to the drowsiness and psychomotor impairment caused by clonazepam. Older adults may also develop confusion and falls.
What this interaction means in plain words
Carbinoxamine and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Clonazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism with central penetration and GABA-A potentiation.
What to do
Advise avoiding driving and hazardous tasks, and consider a non-sedating antihistamine as an alternative. Monitor older patients for confusion and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Clonazepam?
MediHelp rates the interaction as moderate. Carbinoxamine and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating first-generation antihistamine and adds to the drowsiness and psychomotor impairment caused by clonazepam. Older adults may also develop confusion and falls.
How serious is the interaction between Carbinoxamine and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding driving and hazardous tasks, and consider a non-sedating antihistamine as an alternative. Monitor older patients for confusion and falls.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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