Drug interactions
Carbinoxamine + Codeine
Severity: Moderate
Carbinoxamine and Codeine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine that adds to codeine's CNS depression. Drowsiness, impaired psychomotor performance and, rarely, respiratory depression may result.
What this interaction means in plain words
Carbinoxamine and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Codeine belongs to Musculoskeletal.
Why it happens
Additive CNS depression via histamine H1 antagonism and opioid agonism.
What to do
Counsel patients about drowsiness and avoiding driving. Use caution in children and elderly patients and reduce doses if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Codeine?
MediHelp rates the interaction as moderate. Carbinoxamine and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating first-generation antihistamine that adds to codeine's CNS depression. Drowsiness, impaired psychomotor performance and, rarely, respiratory depression may result.
How serious is the interaction between Carbinoxamine and Codeine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and avoiding driving. Use caution in children and elderly patients and reduce doses if sedation is excessive.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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