Drug interactions
Carbinoxamine + Cyclobenzaprine
Severity: Moderate
Carbinoxamine and Cyclobenzaprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have sedating and anticholinergic properties. Taken together they can increase drowsiness, impair psychomotor performance and add to dry mouth, urinary retention and confusion, particularly in older adults.
What this interaction means in plain words
Carbinoxamine and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Cyclobenzaprine belongs to Musculoskeletal.
Why it happens
Additive CNS depression and antimuscarinic effects from two sedating anticholinergic agents.
What to do
Warn the patient about drowsiness and avoid driving or hazardous tasks until the response is known. Consider a non-sedating antihistamine, especially in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Cyclobenzaprine?
MediHelp rates the interaction as moderate. Carbinoxamine and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have sedating and anticholinergic properties. Taken together they can increase drowsiness, impair psychomotor performance and add to dry mouth, urinary retention and confusion, particularly in older adults.
How serious is the interaction between Carbinoxamine and Cyclobenzaprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about drowsiness and avoid driving or hazardous tasks until the response is known. Consider a non-sedating antihistamine, especially in elderly patients.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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