Drug interactions
Carbinoxamine + Diazepam
Severity: Moderate
Carbinoxamine and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine and adds to diazepam-induced drowsiness and psychomotor impairment. The risk is greater in older adults.
What this interaction means in plain words
Carbinoxamine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Diazepam belongs to Musculoskeletal.
Why it happens
Additive CNS depression from H1-receptor antagonism with central penetration and benzodiazepine GABA-A potentiation.
What to do
Counsel patients to avoid driving and hazardous tasks, and use a lower dose of one or both agents in elderly patients. Consider a non-sedating antihistamine if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Diazepam?
MediHelp rates the interaction as moderate. Carbinoxamine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating first-generation antihistamine and adds to diazepam-induced drowsiness and psychomotor impairment. The risk is greater in older adults.
How serious is the interaction between Carbinoxamine and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and hazardous tasks, and use a lower dose of one or both agents in elderly patients. Consider a non-sedating antihistamine if appropriate.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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