Drug interactions
Carbinoxamine + Doxylamine
Severity: Moderate
Carbinoxamine and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are first-generation antihistamines with sedating and anticholinergic properties. Using them together duplicates therapy and increases drowsiness, dry mouth, urinary retention and confusion.
What this interaction means in plain words
Carbinoxamine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Doxylamine belongs to Respiratory.
Why it happens
Additive H1 receptor blockade and muscarinic antagonism, causing additive sedation and anticholinergic effects.
What to do
Avoid using two sedating antihistamines together; choose one agent. Monitor elderly patients closely for anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Doxylamine?
MediHelp rates the interaction as moderate. Carbinoxamine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are first-generation antihistamines with sedating and anticholinergic properties. Using them together duplicates therapy and increases drowsiness, dry mouth, urinary retention and confusion.
How serious is the interaction between Carbinoxamine and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two sedating antihistamines together; choose one agent. Monitor elderly patients closely for anticholinergic toxicity.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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