Drug interactions
Carbinoxamine + Isocarboxazid
Severity: Moderate
Carbinoxamine and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAOIs can prolong and intensify the anticholinergic effects of antihistamines such as carbinoxamine, and both can cause sedation. This may result in marked drowsiness, dry mouth, urinary retention, blurred vision and confusion.
What this interaction means in plain words
Carbinoxamine and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Isocarboxazid belongs to Central Nervous System.
Why it happens
Additive CNS depression, with MAOIs prolonging and intensifying anticholinergic effects.
What to do
Avoid the combination where possible, or use a non-sedating antihistamine. If used, monitor for excess sedation and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Isocarboxazid?
MediHelp rates the interaction as moderate. Carbinoxamine and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAOIs can prolong and intensify the anticholinergic effects of antihistamines such as carbinoxamine, and both can cause sedation. This may result in marked drowsiness, dry mouth, urinary retention, blurred vision and confusion.
How serious is the interaction between Carbinoxamine and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use a non-sedating antihistamine. If used, monitor for excess sedation and anticholinergic effects.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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