Drug interactions
Carbinoxamine + Lorazepam
Severity: Moderate
Carbinoxamine and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine and adds to lorazepam-related drowsiness and psychomotor impairment. Older adults are at greater risk of confusion and falls.
What this interaction means in plain words
Carbinoxamine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and central H1 antagonism.
What to do
Counsel patients to avoid driving and monitor for oversedation; consider a non-sedating antihistamine as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Lorazepam?
MediHelp rates the interaction as moderate. Carbinoxamine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating first-generation antihistamine and adds to lorazepam-related drowsiness and psychomotor impairment. Older adults are at greater risk of confusion and falls.
How serious is the interaction between Carbinoxamine and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and monitor for oversedation; consider a non-sedating antihistamine as an alternative.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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