Drug interactions
Carbinoxamine + Nortriptyline
Severity: Moderate
Carbinoxamine and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating and anticholinergic, so combined use increases drowsiness, dry mouth, urinary retention and confusion. Older patients are at greater risk of impaired cognition and falls.
What this interaction means in plain words
Carbinoxamine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects from an H1 antihistamine and a tricyclic antidepressant.
What to do
Monitor for sedation and anticholinergic effects, and consider a non-sedating antihistamine. Counsel patients on driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Nortriptyline?
MediHelp rates the interaction as moderate. Carbinoxamine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating and anticholinergic, so combined use increases drowsiness, dry mouth, urinary retention and confusion. Older patients are at greater risk of impaired cognition and falls.
How serious is the interaction between Carbinoxamine and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic effects, and consider a non-sedating antihistamine. Counsel patients on driving and alcohol.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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