Drug interactions
Carbinoxamine + Phenelzine
Severity: Moderate
Carbinoxamine and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can prolong and intensify the anticholinergic effects of antihistamines such as carbinoxamine. Additive sedation may also occur. Patients may develop dry mouth, urinary retention, constipation, blurred vision and marked drowsiness.
What this interaction means in plain words
Carbinoxamine and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Phenelzine belongs to Central Nervous System.
Why it happens
Additive anticholinergic and CNS depressant effects, with MAOI enhancement of antihistamine anticholinergic activity.
What to do
Monitor for excessive sedation and anticholinergic effects, and use the lowest effective carbinoxamine dose. Consider a non-sedating antihistamine if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Phenelzine?
MediHelp rates the interaction as moderate. Carbinoxamine and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can prolong and intensify the anticholinergic effects of antihistamines such as carbinoxamine. Additive sedation may also occur. Patients may develop dry mouth, urinary retention, constipation, blurred vision and marked drowsiness.
How serious is the interaction between Carbinoxamine and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and anticholinergic effects, and use the lowest effective carbinoxamine dose. Consider a non-sedating antihistamine if symptoms occur.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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