Drug interactions
Carbonyl iron + Dexlansoprazole
Severity: Moderate
Carbonyl iron and Dexlansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reduced gastric acid impairs conversion of oral iron into absorbable forms, so long-term PPI use may reduce iron absorption and blunt response to oral iron. Iron deficiency can develop or persist.
What this interaction means in plain words
Carbonyl iron and Dexlansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbonyl iron belongs to Miscellaneous; Dexlansoprazole belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH reduces dissolution and solubilization of oral iron, decreasing absorption.
What to do
Monitor ferritin and hemoglobin, and consider a higher iron dose, vitamin C co-administration, or intravenous iron if oral therapy fails.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Carbonyl iron
- Aluminum hydroxide + Carbonyl iron Moderate
- Baloxavir marboxil + Carbonyl iron Moderate
- Calcium acetate + Carbonyl iron Moderate
- Calcium carbonate + Carbonyl iron Moderate
- Calcium + Carbonyl iron Moderate
- Carbidopa-entacapone-levodopa + Carbonyl iron Moderate
Frequently asked questions
Can I take Carbonyl iron with Dexlansoprazole?
MediHelp rates the interaction as moderate. Carbonyl iron and Dexlansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Reduced gastric acid impairs conversion of oral iron into absorbable forms, so long-term PPI use may reduce iron absorption and blunt response to oral iron. Iron deficiency can develop or persist.
How serious is the interaction between Carbonyl iron and Dexlansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ferritin and hemoglobin, and consider a higher iron dose, vitamin C co-administration, or intravenous iron if oral therapy fails.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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