Drug interactions
Carbonyl iron + Vonoprazan
Severity: Moderate
Carbonyl iron and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan causes strong, sustained acid suppression, which can reduce absorption of oral carbonyl iron. Prolonged co-use may lead to poor response to iron therapy.
What this interaction means in plain words
Carbonyl iron and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbonyl iron belongs to Miscellaneous; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH reduces iron dissolution and absorption.
What to do
Monitor ferritin, transferrin saturation and hemoglobin during long-term co-therapy. Consider intravenous iron if oral therapy is ineffective.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbonyl iron
- Aluminum hydroxide + Carbonyl iron Moderate
- Baloxavir marboxil + Carbonyl iron Moderate
- Calcium acetate + Carbonyl iron Moderate
- Calcium carbonate + Carbonyl iron Moderate
- Calcium + Carbonyl iron Moderate
- Carbidopa-entacapone-levodopa + Carbonyl iron Moderate
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Carbonyl iron with Vonoprazan?
MediHelp rates the interaction as moderate. Carbonyl iron and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan causes strong, sustained acid suppression, which can reduce absorption of oral carbonyl iron. Prolonged co-use may lead to poor response to iron therapy.
How serious is the interaction between Carbonyl iron and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ferritin, transferrin saturation and hemoglobin during long-term co-therapy. Consider intravenous iron if oral therapy is ineffective.
What other medicines interact with Carbonyl iron?
MediHelp also lists interactions of Carbonyl iron with, for example, Aluminum hydroxide, Baloxavir marboxil, Calcium acetate. The full list is on the Carbonyl iron page.
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