Drug interactions
Carboplatin + Oxaliplatin
Severity: Moderate
Carboplatin and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are platinum agents with overlapping toxicities including myelosuppression, neurotoxicity, ototoxicity and some renal toxicity. Combining them is rarely done and adds toxicity without clear benefit.
What this interaction means in plain words
Carboplatin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carboplatin belongs to Oncology; Oxaliplatin belongs to Oncology.
Why it happens
Additive platinum-related toxicity affecting kidneys, cochlea, nerves and bone marrow.
What to do
Avoid combining platinum agents unless specifically protocol-directed. If used, monitor renal function, blood counts, hearing and neuropathy symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carboplatin
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Carboplatin with Oxaliplatin?
MediHelp rates the interaction as moderate. Carboplatin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are platinum agents with overlapping toxicities including myelosuppression, neurotoxicity, ototoxicity and some renal toxicity. Combining them is rarely done and adds toxicity without clear benefit.
How serious is the interaction between Carboplatin and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining platinum agents unless specifically protocol-directed. If used, monitor renal function, blood counts, hearing and neuropathy symptoms.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
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