Drug interactions
Carfilzomib + Glecaprevir / pibrentasvir
Severity: Minor
Carfilzomib and Glecaprevir / pibrentasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and could increase exposure to P-gp substrates such as carfilzomib. Since carfilzomib is cleared mainly by peptidases, the increase is expected to be modest.
What this interaction means in plain words
Carfilzomib and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glecaprevir and pibrentasvir inhibit intestinal and cellular P-gp efflux, which may modestly raise carfilzomib levels.
What to do
No dose adjustment is generally needed; monitor for carfilzomib toxicity such as cardiac, pulmonary and hematologic effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carfilzomib
- Carfilzomib + Etrasimod Major
- Carfilzomib + Ropeginterferon alfa 2b Major
- Carfilzomib + Dichlorphenamide Moderate
- Carfilzomib + Palifermin Moderate
- Carfilzomib + Ponesimod Moderate
- Carfilzomib + Siponimod Moderate
Frequently asked questions
Can I take Carfilzomib with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as minor. Carfilzomib and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-glycoprotein and could increase exposure to P-gp substrates such as carfilzomib. Since carfilzomib is cleared mainly by peptidases, the increase is expected to be modest.
How serious is the interaction between Carfilzomib and Glecaprevir / pibrentasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for carfilzomib toxicity such as cardiac, pulmonary and hematologic effects.
What other medicines interact with Carfilzomib?
MediHelp also lists interactions of Carfilzomib with, for example, Etrasimod, Ropeginterferon alfa 2b, Dichlorphenamide. The full list is on the Carfilzomib page.
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