Drug interactions
Carfilzomib + Etrasimod
Severity: Major
Carfilzomib and Etrasimod: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod reduces circulating lymphocytes and carfilzomib is immunosuppressive and myelosuppressive. Together they may increase infection risk. The combination has not been studied.
What this interaction means in plain words
Carfilzomib and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carfilzomib belongs to Oncology; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from S1P receptor modulation and proteasome inhibition.
What to do
Avoid concurrent use where possible. If it is needed, monitor for infection and lymphocyte counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Carfilzomib
- Carfilzomib + Ropeginterferon alfa 2b Major
- Carfilzomib + Dichlorphenamide Moderate
- Carfilzomib + Palifermin Moderate
- Carfilzomib + Ponesimod Moderate
- Carfilzomib + Siponimod Moderate
- Berotralstat + Carfilzomib Minor
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Carfilzomib with Etrasimod?
MediHelp rates the interaction as major. Carfilzomib and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod reduces circulating lymphocytes and carfilzomib is immunosuppressive and myelosuppressive. Together they may increase infection risk. The combination has not been studied.
How serious is the interaction between Carfilzomib and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If it is needed, monitor for infection and lymphocyte counts.
What other medicines interact with Carfilzomib?
MediHelp also lists interactions of Carfilzomib with, for example, Ropeginterferon alfa 2b, Dichlorphenamide, Palifermin. The full list is on the Carfilzomib page.
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