Drug interactions
Carfilzomib + Palifermin
Severity: Moderate
Carfilzomib and Palifermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin given near cytotoxic therapy may increase the severity and duration of mucositis. Carfilzomib is an antineoplastic, so the same precaution applies.
What this interaction means in plain words
Carfilzomib and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carfilzomib belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin stimulates epithelial proliferation, sensitizing mucosal cells to cytotoxic injury.
What to do
Do not give palifermin within 24 hours before, during or within 24 hours after carfilzomib. Monitor for mucositis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carfilzomib
- Carfilzomib + Etrasimod Major
- Carfilzomib + Ropeginterferon alfa 2b Major
- Carfilzomib + Dichlorphenamide Moderate
- Carfilzomib + Ponesimod Moderate
- Carfilzomib + Siponimod Moderate
- Berotralstat + Carfilzomib Minor
Other interactions of Palifermin
Frequently asked questions
Can I take Carfilzomib with Palifermin?
MediHelp rates the interaction as moderate. Carfilzomib and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin given near cytotoxic therapy may increase the severity and duration of mucositis. Carfilzomib is an antineoplastic, so the same precaution applies.
How serious is the interaction between Carfilzomib and Palifermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during or within 24 hours after carfilzomib. Monitor for mucositis.
What other medicines interact with Carfilzomib?
MediHelp also lists interactions of Carfilzomib with, for example, Etrasimod, Ropeginterferon alfa 2b, Dichlorphenamide. The full list is on the Carfilzomib page.
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