Drug interactions
Cariprazine + Clozapine
Severity: Moderate
Cariprazine and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antipsychotics, and combined use increases sedation, orthostatic hypotension and metabolic effects. Clozapine adds risks such as seizures, myocarditis and agranulocytosis, and the combination is generally used only in specialist care for treatment-resistant illness.
What this interaction means in plain words
Cariprazine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Clozapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects from dopamine, serotonin, histamine and adrenergic receptor antagonism.
What to do
Use only under specialist supervision, with the lowest effective doses. Monitor sedation, blood pressure, metabolic parameters and clozapine blood counts as usual.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Cariprazine with Clozapine?
MediHelp rates the interaction as moderate. Cariprazine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antipsychotics, and combined use increases sedation, orthostatic hypotension and metabolic effects. Clozapine adds risks such as seizures, myocarditis and agranulocytosis, and the combination is generally used only in specialist care for treatment-resistant illness.
How serious is the interaction between Cariprazine and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only under specialist supervision, with the lowest effective doses. Monitor sedation, blood pressure, metabolic parameters and clozapine blood counts as usual.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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