Drug interactions
Cariprazine + Codeine
Severity: Moderate
Cariprazine and Codeine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine and codeine can both cause drowsiness and dizziness, and together may produce additive sedation and psychomotor impairment. Respiratory depression is more likely at high opioid doses.
What this interaction means in plain words
Cariprazine and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Codeine belongs to Musculoskeletal.
Why it happens
Additive CNS depression through pharmacodynamic synergism.
What to do
Use the lowest effective codeine dose for the shortest time and monitor sedation. Counsel patients about driving and hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Codeine?
MediHelp rates the interaction as moderate. Cariprazine and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cariprazine and codeine can both cause drowsiness and dizziness, and together may produce additive sedation and psychomotor impairment. Respiratory depression is more likely at high opioid doses.
How serious is the interaction between Cariprazine and Codeine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective codeine dose for the shortest time and monitor sedation. Counsel patients about driving and hazardous activities.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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