Drug interactions
Cariprazine + Diazepam
Severity: Moderate
Cariprazine and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine and diazepam both cause CNS depression, and together they may increase somnolence and impair alertness and motor skills. The combination is commonly used but needs attention to sedation.
What this interaction means in plain words
Cariprazine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Diazepam belongs to Musculoskeletal.
Why it happens
Additive CNS depression via GABA-A potentiation and antipsychotic receptor antagonism.
What to do
Monitor for oversedation, orthostatic dizziness and falls, particularly when starting or increasing either drug. Advise against driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Diazepam?
MediHelp rates the interaction as moderate. Cariprazine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cariprazine and diazepam both cause CNS depression, and together they may increase somnolence and impair alertness and motor skills. The combination is commonly used but needs attention to sedation.
How serious is the interaction between Cariprazine and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, orthostatic dizziness and falls, particularly when starting or increasing either drug. Advise against driving until tolerance is established.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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