Drug interactions
Cariprazine + Diphenoxylate-atropine
Severity: Moderate
Cariprazine and Diphenoxylate-atropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine can cause somnolence and impair judgement and motor skills. With diphenoxylate, additive sedation may occur.
What this interaction means in plain words
Cariprazine and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression.
What to do
Counsel on drowsiness and avoid hazardous activities; use the lowest effective diphenoxylate dose and review if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Diphenoxylate-atropine?
MediHelp rates the interaction as moderate. Cariprazine and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cariprazine can cause somnolence and impair judgement and motor skills. With diphenoxylate, additive sedation may occur.
How serious is the interaction between Cariprazine and Diphenoxylate-atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and avoid hazardous activities; use the lowest effective diphenoxylate dose and review if sedation is excessive.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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