Drug interactions
Cariprazine + Frovatriptan
Severity: Moderate
Cariprazine and Frovatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on serotonin pathways, so serotonin toxicity is a theoretical concern when they are combined. Antipsychotics also carry a risk of neuroleptic malignant syndrome. Clinical reports for this pair are lacking and the risk appears low.
What this interaction means in plain words
Cariprazine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Frovatriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects from 5-HT1B/1D agonism and cariprazine's 5-HT1A partial agonism; not firmly established.
What to do
Educate the patient to report agitation, tremor, sweating, fever or muscle rigidity. Monitor mental status and autonomic signs after starting or changing either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cariprazine and Frovatriptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cariprazine
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Cariprazine with Frovatriptan?
MediHelp rates the interaction as moderate. Cariprazine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on serotonin pathways, so serotonin toxicity is a theoretical concern when they are combined. Antipsychotics also carry a risk of neuroleptic malignant syndrome. Clinical reports for this pair are lacking and the risk appears low.
How serious is the interaction between Cariprazine and Frovatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Educate the patient to report agitation, tremor, sweating, fever or muscle rigidity. Monitor mental status and autonomic signs after starting or changing either drug.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
