Drug interactions
Cariprazine + Ivosidenib
Severity: Moderate
Cariprazine and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib is a CYP3A4 inducer, which may lower cariprazine and active metabolite concentrations. This could lead to loss of antipsychotic or mood-stabilizing efficacy and relapse of symptoms.
What this interaction means in plain words
Cariprazine and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Ivosidenib belongs to Oncology.
Why it happens
Induction of CYP3A4 by ivosidenib increases cariprazine metabolism.
What to do
Monitor for loss of psychiatric control and adjust the cariprazine dose if needed. Reassess dosing when ivosidenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cariprazine and Ivosidenib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cariprazine
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Cariprazine with Ivosidenib?
MediHelp rates the interaction as moderate. Cariprazine and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib is a CYP3A4 inducer, which may lower cariprazine and active metabolite concentrations. This could lead to loss of antipsychotic or mood-stabilizing efficacy and relapse of symptoms.
How serious is the interaction between Cariprazine and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of psychiatric control and adjust the cariprazine dose if needed. Reassess dosing when ivosidenib is stopped.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
