Drug interactions
Cariprazine + Larotrectinib
Severity: Minor
Cariprazine and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak inhibitory potential and may slightly raise cariprazine concentrations. Any effect is expected to be small and of limited clinical relevance.
What this interaction means in plain words
Cariprazine and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cariprazine belongs to Central Nervous System; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition reduces cariprazine metabolism.
What to do
No dose change is required; monitor for akathisia and sedation and adjust cariprazine if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cariprazine
Other interactions of Larotrectinib
Frequently asked questions
Can I take Cariprazine with Larotrectinib?
MediHelp rates the interaction as minor. Cariprazine and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with weak inhibitory potential and may slightly raise cariprazine concentrations. Any effect is expected to be small and of limited clinical relevance.
How serious is the interaction between Cariprazine and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required; monitor for akathisia and sedation and adjust cariprazine if adverse effects emerge.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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