Drug interactions
Cariprazine + Nelfinavir
Severity: Major
Cariprazine and Nelfinavir: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 strongly enough to increase cariprazine exposure. Higher levels raise the likelihood of dose-related adverse effects such as akathisia, parkinsonism and sedation.
What this interaction means in plain words
Cariprazine and Nelfinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cariprazine belongs to Central Nervous System; Nelfinavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition decreases clearance of cariprazine and its active metabolites.
What to do
Reduce the cariprazine dose per labeling when combined with a strong CYP3A4 inhibitor, and monitor for movement disorders and sedation. Adjust again once nelfinavir is discontinued.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cariprazine
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Cariprazine with Nelfinavir?
MediHelp rates the interaction as major. Cariprazine and Nelfinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nelfinavir inhibits CYP3A4 strongly enough to increase cariprazine exposure. Higher levels raise the likelihood of dose-related adverse effects such as akathisia, parkinsonism and sedation.
How serious is the interaction between Cariprazine and Nelfinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the cariprazine dose per labeling when combined with a strong CYP3A4 inhibitor, and monitor for movement disorders and sedation. Adjust again once nelfinavir is discontinued.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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