Drug interactions
Cariprazine + Nortriptyline
Severity: Moderate
Cariprazine and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause sedation, dizziness and orthostatic hypotension, so combined use may impair alertness and raise fall risk. Cariprazine has a long half-life, so effects can persist.
What this interaction means in plain words
Cariprazine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive CNS depressant and hypotensive effects.
What to do
Monitor sedation and orthostatic blood pressure, especially during dose titration, and counsel on driving and fall precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Nortriptyline?
MediHelp rates the interaction as moderate. Cariprazine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause sedation, dizziness and orthostatic hypotension, so combined use may impair alertness and raise fall risk. Cariprazine has a long half-life, so effects can persist.
How serious is the interaction between Cariprazine and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure, especially during dose titration, and counsel on driving and fall precautions.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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