Drug interactions
Cariprazine + Phenelzine
Severity: Moderate
Cariprazine and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine with an MAOI may add to serotonergic and dopaminergic effects, with a small risk of serotonin syndrome or neuroleptic malignant syndrome. Additive hypotension may also occur.
What this interaction means in plain words
Cariprazine and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Cariprazine partial agonism at dopamine D2/D3 and 5-HT1A receptors may add to the increased monoamine levels from MAO inhibition.
What to do
Monitor for agitation, clonus, hyperthermia, rigidity and blood pressure changes, particularly after initiation or dose increases. Stop one agent if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Phenelzine?
MediHelp rates the interaction as moderate. Cariprazine and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cariprazine with an MAOI may add to serotonergic and dopaminergic effects, with a small risk of serotonin syndrome or neuroleptic malignant syndrome. Additive hypotension may also occur.
How serious is the interaction between Cariprazine and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, clonus, hyperthermia, rigidity and blood pressure changes, particularly after initiation or dose increases. Stop one agent if toxicity is suspected.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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