Drug interactions
Cariprazine + Selegiline
Severity: Moderate
Cariprazine and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on dopaminergic and serotonergic systems. Selegiline is a dopamine agonist-like MAO-B inhibitor, so it may oppose the effect of cariprazine and worsen psychosis. The combination also carries a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome.
What this interaction means in plain words
Cariprazine and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition at dopamine receptors, with a possible additive serotonergic effect; the exact mechanism is not firmly established.
What to do
Monitor for loss of antipsychotic effect, worsening of psychosis, and signs of serotonin syndrome such as agitation, tremor, hyperthermia and clonus. Review the need for both drugs if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Cariprazine with Selegiline?
MediHelp rates the interaction as moderate. Cariprazine and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on dopaminergic and serotonergic systems. Selegiline is a dopamine agonist-like MAO-B inhibitor, so it may oppose the effect of cariprazine and worsen psychosis. The combination also carries a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome.
How serious is the interaction between Cariprazine and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antipsychotic effect, worsening of psychosis, and signs of serotonin syndrome such as agitation, tremor, hyperthermia and clonus. Review the need for both drugs if symptoms appear.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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