Drug interactions
Cariprazine + Sodium oxybate
Severity: Major
Cariprazine and Sodium oxybate: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium oxybate causes profound CNS and respiratory depression, and its labeling advises against combining with other CNS depressants. Cariprazine adds sedation, increasing the risk of excessive sedation, respiratory depression and impaired arousal.
What this interaction means in plain words
Cariprazine and Sodium oxybate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cariprazine belongs to Central Nervous System; Sodium oxybate belongs to Central Nervous System.
Why it happens
Additive central nervous system and respiratory depression.
What to do
Avoid the combination where possible; if necessary, reduce the oxybate dose or consider alternatives and monitor sedation and respiration closely, especially at night.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cariprazine
Other interactions of Sodium oxybate
- Alprazolam + Sodium oxybate Contraindicated
- Amobarbital + Sodium oxybate Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Cariprazine with Sodium oxybate?
MediHelp rates the interaction as major. Cariprazine and Sodium oxybate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sodium oxybate causes profound CNS and respiratory depression, and its labeling advises against combining with other CNS depressants. Cariprazine adds sedation, increasing the risk of excessive sedation, respiratory depression and impaired arousal.
How serious is the interaction between Cariprazine and Sodium oxybate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if necessary, reduce the oxybate dose or consider alternatives and monitor sedation and respiration closely, especially at night.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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