Drug interactions
Cariprazine + Suvorexant
Severity: Moderate
Cariprazine and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant is an orexin receptor antagonist hypnotic that causes somnolence and next-day impairment. Combined with cariprazine, sedation and psychomotor impairment may be increased.
What this interaction means in plain words
Cariprazine and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Use the lowest suvorexant dose and monitor next-day drowsiness; counsel patients about driving and dose adjustment if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Suvorexant
Frequently asked questions
Can I take Cariprazine with Suvorexant?
MediHelp rates the interaction as moderate. Cariprazine and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Suvorexant is an orexin receptor antagonist hypnotic that causes somnolence and next-day impairment. Combined with cariprazine, sedation and psychomotor impairment may be increased.
How serious is the interaction between Cariprazine and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest suvorexant dose and monitor next-day drowsiness; counsel patients about driving and dose adjustment if impairment occurs.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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