Drug interactions
Cariprazine + Zuranolone
Severity: Moderate
Cariprazine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes marked somnolence and impaired driving ability, and cariprazine adds sedative effects. The combination may increase psychomotor impairment and CNS depression.
What this interaction means in plain words
Cariprazine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A modulation and antipsychotic sedation.
What to do
Consider reducing the zuranolone dose if excessive sedation occurs. Counsel patients not to drive or operate machinery for at least 12 hours after the dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Cariprazine with Zuranolone?
MediHelp rates the interaction as moderate. Cariprazine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes marked somnolence and impaired driving ability, and cariprazine adds sedative effects. The combination may increase psychomotor impairment and CNS depression.
How serious is the interaction between Cariprazine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the zuranolone dose if excessive sedation occurs. Counsel patients not to drive or operate machinery for at least 12 hours after the dose.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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