Drug interactions
Carisoprodol + Clomipramine
Severity: Moderate
Carisoprodol and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a sedating tricyclic antidepressant, and with carisoprodol it can cause additive drowsiness, dizziness and psychomotor impairment. Anticholinergic effects and falls may be more troublesome in older adults.
What this interaction means in plain words
Carisoprodol and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Clomipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Monitor for oversedation and falls, and use the lowest effective doses. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carisoprodol
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Carisoprodol with Clomipramine?
MediHelp rates the interaction as moderate. Carisoprodol and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a sedating tricyclic antidepressant, and with carisoprodol it can cause additive drowsiness, dizziness and psychomotor impairment. Anticholinergic effects and falls may be more troublesome in older adults.
How serious is the interaction between Carisoprodol and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and falls, and use the lowest effective doses. Advise against driving until the response is known.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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