Drug interactions
Carisoprodol + Clorazepate
Severity: Major
Carisoprodol and Clorazepate: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clorazepate is a benzodiazepine, and with carisoprodol it can cause profound sedation, ataxia and respiratory depression. Misuse and overdose risk is increased.
What this interaction means in plain words
Carisoprodol and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carisoprodol belongs to Musculoskeletal; Clorazepate belongs to Central Nervous System.
Why it happens
Additive GABA-A mediated CNS depression.
What to do
Avoid concurrent use where possible, or limit doses and duration and monitor sedation and respiratory function. Counsel against alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Carisoprodol
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Carisoprodol with Clorazepate?
MediHelp rates the interaction as major. Carisoprodol and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clorazepate is a benzodiazepine, and with carisoprodol it can cause profound sedation, ataxia and respiratory depression. Misuse and overdose risk is increased.
How serious is the interaction between Carisoprodol and Clorazepate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, or limit doses and duration and monitor sedation and respiratory function. Counsel against alcohol and driving.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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