Drug interactions
Carisoprodol + Eslicarbazepine
Severity: Moderate
Carisoprodol and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine can inhibit CYP2C19, the main enzyme converting carisoprodol to meprobamate. Carisoprodol exposure may therefore rise, with more sedation and dizziness, while meprobamate formation falls.
What this interaction means in plain words
Carisoprodol and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Eslicarbazepine inhibits CYP2C19-mediated metabolism of carisoprodol.
What to do
Monitor for excessive sedation, dizziness and psychomotor impairment when starting or increasing eslicarbazepine. Reduce the carisoprodol dose if adverse CNS effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carisoprodol
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Carisoprodol with Eslicarbazepine?
MediHelp rates the interaction as moderate. Carisoprodol and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine can inhibit CYP2C19, the main enzyme converting carisoprodol to meprobamate. Carisoprodol exposure may therefore rise, with more sedation and dizziness, while meprobamate formation falls.
How serious is the interaction between Carisoprodol and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and psychomotor impairment when starting or increasing eslicarbazepine. Reduce the carisoprodol dose if adverse CNS effects appear.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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