Drug interactions
Carisoprodol + Hydroxyzine
Severity: Moderate
Carisoprodol and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine and, with carisoprodol, can produce additive drowsiness and impaired psychomotor function. The risk is greater in older adults and with higher doses.
What this interaction means in plain words
Carisoprodol and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Hydroxyzine belongs to Respiratory.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective doses and counsel the patient about sedation and driving. Consider an alternative in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carisoprodol
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Carisoprodol with Hydroxyzine?
MediHelp rates the interaction as moderate. Carisoprodol and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is a sedating antihistamine and, with carisoprodol, can produce additive drowsiness and impaired psychomotor function. The risk is greater in older adults and with higher doses.
How serious is the interaction between Carisoprodol and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel the patient about sedation and driving. Consider an alternative in older adults.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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