Drug interactions
Carisoprodol + Iloperidone
Severity: Moderate
Carisoprodol and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a sedating antipsychotic that can cause somnolence and dizziness, and carisoprodol adds further CNS depression. Orthostatic hypotension from iloperidone may increase the risk of falls.
What this interaction means in plain words
Carisoprodol and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from antipsychotic receptor blockade and GABA-ergic sedation by carisoprodol.
What to do
Monitor for oversedation and orthostatic symptoms, and advise caution with driving. Lower doses may be needed in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carisoprodol
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Carisoprodol with Iloperidone?
MediHelp rates the interaction as moderate. Carisoprodol and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is a sedating antipsychotic that can cause somnolence and dizziness, and carisoprodol adds further CNS depression. Orthostatic hypotension from iloperidone may increase the risk of falls.
How serious is the interaction between Carisoprodol and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostatic symptoms, and advise caution with driving. Lower doses may be needed in older patients.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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