Drug interactions
Carisoprodol + Lonafarnib
Severity: Moderate
Carisoprodol and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib inhibits CYP2C19 and other enzymes, which may raise carisoprodol exposure. This could increase sedation and the other adverse effects of carisoprodol.
What this interaction means in plain words
Carisoprodol and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Lonafarnib belongs to Miscellaneous.
Why it happens
Lonafarnib inhibition of CYP2C19-mediated metabolism of carisoprodol.
What to do
Monitor for excess sedation and consider a lower carisoprodol dose. Use another muscle relaxant if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carisoprodol
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Carisoprodol with Lonafarnib?
MediHelp rates the interaction as moderate. Carisoprodol and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib inhibits CYP2C19 and other enzymes, which may raise carisoprodol exposure. This could increase sedation and the other adverse effects of carisoprodol.
How serious is the interaction between Carisoprodol and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and consider a lower carisoprodol dose. Use another muscle relaxant if sedation is troublesome.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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