Drug interactions
Carbamazepine + Lonafarnib
Severity: Contraindicated
Carbamazepine and Lonafarnib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine strongly induces CYP3A4 and is expected to markedly reduce exposure to lonafarnib, a sensitive CYP3A substrate, compromising its efficacy. Labeling contraindicates strong or moderate CYP3A inducers.
What this interaction means in plain words
Carbamazepine and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbamazepine belongs to Central Nervous System; Lonafarnib belongs to Miscellaneous.
Why it happens
Carbamazepine induces CYP3A4, increasing lonafarnib clearance.
What to do
Avoid; use a non-inducing anticonvulsant for the duration of lonafarnib therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
- Crizotinib + Lonafarnib Contraindicated
Frequently asked questions
Can I take Carbamazepine with Lonafarnib?
MediHelp rates the interaction as contraindicated. Carbamazepine and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine strongly induces CYP3A4 and is expected to markedly reduce exposure to lonafarnib, a sensitive CYP3A substrate, compromising its efficacy. Labeling contraindicates strong or moderate CYP3A inducers.
How serious is the interaction between Carbamazepine and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; use a non-inducing anticonvulsant for the duration of lonafarnib therapy.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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